The objective of the present study was to quantify the association between 21 known myostatin mutations with calving difficulty, carcass fat, carcass conformation, and carcass weight in 12 prominent cattle breeds. Out of all segregating myostatin variants, the nt821 deletion had the greatest observed association with calving difficulty when the homozygous deletion was carried by either the calf or the dam. However, the association between the calf’s nt821 genotype and calving difficulty varied depending on the nt821 genotype of the dam. The F94L, Q204X, and nt821 mutations generally had the greatest association with all three carcass traits, resulting in heavier and more conformed carcasses. The nt374_51, F94L, and E226X mutations were all associated with improved carcass merit while having minimal expected consequences on calving difficulty; therefore, animals carrying these mutations could potentially have desirable genetic merit for both calving difficulty and carcass merit. Similarly, depending on the genotype of the dam, a bull carrying two copies of the nt821 deletion could give rise to progeny that have improved carcass merit while minimizing the associated risk of calving difficulty.

Read the full article in the Journal of Animal Science.